Citrate, Malate And Alkali Content In Commonly Consumed Diet Sodas

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Investigative Urology
Citrate, Malate and Alkali Articles in Commonly Consumed Diet plan Sodas: Implications for Nephrolithiasis Treatment
c Litholink Corp., Chicago, Illinois, and Nephrology Section, New York Harbor Veterans Affairs INFIRMARY, New York, New York
d Section of Urology, St. Vincent's Hospital and NY University School of Medicine, NY, New York
Received 11 September 2009, Available on the web 18 April 2010
Citrate is a known inhibitor of calcium stone formation. Dietary citrate and alkali intake may have an effect on citraturia. Increasing alkali intake also boosts urine pH, that may help prevent the crystals stones. We determined citrate, malate and total alkali concentrations in frequently consumed diet sodas to greatly help immediate dietary recommendations in individuals with hypocitraturic calcium mineral or the crystals nephrolithiasis.
Materials and Methods
Citrate and malate were measured in a lemonade drink commonly used to take care of hypocitraturic calcium mineral nephrolithiasis and in 15 diet sodas. Anions were measured by ion chromatography. The pH of each drink was measured to allow calculation of the unprotonated anion concentration using the known pK of citric and malic acidity. Total alkali equivalents had been calculated for each drink. Statistical evaluation was carried out using Pearson's correlation coefficient.
Several sodas contained an amount of citrate equal to or greater than that of alkali and total alkali like a lemonade beverage commonly used to treat hypocitraturic calcium nephrolithiasis (6.30 mEq/l citrate as alkali and 6.30 as total alkali). These sodas had been Diet Sunkist® Orange, Diet plan 7Up®, Sprite No, Diet Canada Dry® Ginger Ale, Sierra Mist® Free, Diet plan Orange Crush®, Fresca® and Diet Mountain Dew®. Colas, including Caffeine Free Diet plan Coke®, Coke Zero, Caffeine gluten free banana muffins almond flour Diet Pepsi® and Diet Coke with Lime, got the cheapest total alkali (significantly less than 1.0 mEq/l). There is no significant correlation between beverage pH and total alkali articles.
Many commonly consumed diet sodas contain moderate levels of citrate as alkali and total alkali. These details is effective for dietary suggestions in individuals with calcium mineral nephrolithiasis, specifically people that have hypocitraturia. It could also become useful in sufferers with low urine pH and uric acid stones. Beverage malate content can be essential since malate ingestion increases the total alkali delivered, which augments citraturia and raises urine pH.
Supplementary material for this article can be acquired at /journalofurology.
Correspondence: Section of Urology, GRB 1102, Massachusetts General Medical center, 55 Fruit St., Boston, Massachusetts 02114 (telephone: 617-726-3512; FAX: 617-726-6131)
Financial interest and/or various other relationship with PercSys and Ravine Group.

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